Tuesday, December 29, 2009

An Interview with Margam Chandrasekaran, Chief Scientist at BSI

"BIO-SCAFFOLD International (BSI), a homegrown biotechnology firm, obtained another important certification earlier this month for its newest product: Alvelac, a bio-scaffold which allows a tooth socket to retain its structure after a dental extraction, supporting the bone as it heals naturally. The company was awarded the CE Mark for meeting European Union consumer health requirements, after it earlier won certification from the Food and Drug Administration (FDA) in the US." Learn more from this article published on Business Times, Tues, Dec 22, Pg 10.

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Tuesday, December 1, 2009

Interview with Dr. Chong kai Chuan, Clinical Director of Q&M Dental Surgery

Listen to the interview with Dr. Chong, Clinical Director of Q&M Dental Surgery, for indepth information on dentistry.   Q01 - Many people find implants relatively expensive. What is your opinion?     Q02 - What are the pros and cons of tooth extraction and implants?   Q03 - When is it necessary to extract a tooth? [...]

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Tuesday, November 17, 2009

Bone Grafting at Time of Extraction: Can This Get Costly?

Interesting topic for your reading - Bone Grafting at Time of Extraction: Can This Get Costly?

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Interesting discussion on Extraction Site

Read this interesting discussion "Grafting an Extraction Site even when the Buccal Cortical Plate is Intact?".

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Monday, November 16, 2009

Oral Health

Missing teeth can lead to a host of health problems. Learn more from this article published on TODAY,  Tues, 17 Nov 2009, Pg 44.

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Friday, October 30, 2009

Sharing Of Thought Over A Comment

Good personal opinion on socket preservation. Since there is a direct remark on use of Alvelac also, we would like to add our comments to enlighten on the need for socket preservation. As indicated in the comments, immediate implant is preferred in sockets having good integrity following a tooth extraction. However, the comment fails to highlight other factors that are important for deciding on immediate implants. Common factors include, patients financial condition, success rates associated with immediate implants notwithstanding the fact that it would be the best method for immediate preservation of aesthetics and similar. As mentioned in the article, there are other socket preservation techniques that use the conventional methodology of packing the socket. As an experienced person in dentistry one would agree that blood clot is critical for natural healing and the conventional methods tend to occupy the space required for the blood clot which affects the natural healing p! rocess. On the other hand the concept behind Alvelac is to provide the necessary space for the blood clot while restricting the collapse of buccal/lingual walls of the ridge. For the concept to work, it is not necessary to have the socket with absolute buccal or lingual wall integrity and even in partially defective cases this should work. The requirement is that the Alvelac should engage and not to be left hanging in the socket. So in conclusion, socket preservation is an insurance for patients to delay their decision on future choice of teeth restoration and Alvelac provides this in a natural and cost effective way.

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Tuesday, October 27, 2009

Quote from Senior Minister of State for Trade and Industry & Education

In describing the landscape for Medical Technology Innovation in Singapore , Mr S Iswaran, Senior Minister of State for Trade and Industry & Education, "…SIMTech's collaboration with Bio-Scaffold International, a Singapore-based biotechnology company. …resulted in the development of a new technology for processing scaffolds using FDA-approved biopolymers.  The accolades for the product reflect Singapore's world-class R&D standards which is growing in competitiveness vis a vis industry players in USA, Japan and India - AT THE LAUNCH OF THE MEDTECH MANUFACTURING CONSORTIUM, OCTOBER 2009. Read More here http://www.news.gov.sg/public/sgpc/en/media_releases/agencies/mti/speech/S-20091013-2

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Monday, September 28, 2009

Interview with Dr. Cliff K.S. Ong of Atria-Pan Dental Group

 dr-cliff-ong "Dr Ong .. advocates Socket Preservation because his mantra, is that Prevention is Better than Cure".. bone preservation and esthetic dental implants play a more important role now….. with more people opting for prevention care, the importance of sufficient bones support becomes a spotlight issue." Dr Cliff K.S. Ong, B.D.S. (Singapore), M.D.S (Oral & Maxillofacial Surgery), F.D.S.R.C.S (England), F.F.D.R.C.S (Ireland) Atria-Pan Dental Group
People who have lost their teeth from a dental extraction may experience difficulties in chewing food, speak properly, or facial appearances may be affected. The area of the jaw bone holding a tooth in place is called a tooth socket. After extraction, the bone supporting this tooth rapidly melts away (resorption). For placement of a natural-looking (esthetic) bridge or implant after extraction, good bone support is a must. Very often, an ugly-looking tooth replacement is due to loss of this bone support. Having said however, an expensive and potentially painful procedure called bone grafting can be done to restore the lost bone to allow an esthetic restoration of teeth. A recent new technique called Socket Preservation minimizes this bone lost after extraction and preserves the bone in advance, allowing tooth replacement that satisfies esthetic and functional criteria. This technique involves placement of a scaffold to guide bone growth and prevent resorption into the extraction socket immediately after extraction. This technique [...]

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Monday, September 14, 2009

Iliac

Iliac: uppermost and largest bone of the pelvis.

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Cranioplasty

Cranioplasty: it is a surgical repair of a defect or deformity of a skull.

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Dental Info Pack

Here Fellow Dentists may download the information pack for their use in clinics. 1. BSI Corporate Profile 1. Dentists Explanatory Poster 2. Dentists Explanatory Sheet 3. Patient Care Tips 4. Product Brochure 5. Product Data Sheet

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Abutments

Abutments: A tooth, root, or implant used for support and retention of a fixed or removable prosthesis.

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Doctor's Bone Profile

I'm a dentist specializing in jaw bone and socket preservation related issues.

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Wednesday, September 9, 2009

Directory Listing



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Monday, September 7, 2009

Bio-Scaffold wins at FDI Annual World Dental Congress Singapore

LOCAL BIO-DEGRADABLE BONE REGENERATOR WINS AT FDI ANNUAL WORLD DENTAL CONGRESS SINGAPORE 2009 4 September 2009, Singapore - Singapore's homegrown biotech company Bio-Scaffold International ("BSI"), with its groundbreaking bio-degradable bone regenerator, beat 200 submissions from more than 40 countries to win the Poster Presentation award at the FDI Annual World Dental Congress ("FDI") held at the Suntec Singapore International Convention & Exhibition Centre from the 2-5 September. At this international event attended by more than 10,000 delegates from all over the world, the award seeks to recognize excellence in the R&D efforts of practitioners and researchers to advance new technologies, products and innovations in the global dental industry. [caption id="attachment_567" align="alignleft" width="150" caption="Professor Victor Fan receiving the award"]Professor Victor Fan receiving the award[/caption] BSI's invention represents Singaporean's only entry this year to have made it to the top 12 submissions amongst others from Japan, China, Taiwan, India, Poland, Iran, USA, Kazakhstan, Austria and many more. The final victory was won by 6 top presentations - each winner bagging Euro 1,500 for future R&D work as well as free registration to next year's FDI event in Brazil.  The winners were selected by an international panel of judges that included Dr Nermin Yamalik from the FDI Educational Committee and Mr Ns Biljani from Unilever that sponsored the international competition. Professor Victor Fan, consultant Oral and Maxillofacial surgeon at the National University Hospital, who conducted the c [...]

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The Importance of Socket Preservation

BIO-SCAFFOLD INTERNATIONAL (BSI)

Bio-Scaffold International (BSI), a Singapore based and innovative biotechnology Company, specializes in the development of bio-scaffolds for the replacement of human tissues including bones, joints and ligaments. With the corporate headquarter strategically located in Singapore and through mutually rewarding collaboration with her esteem partners, BSI is well positioned to provide such innovations.

BSI's strengths are in its R&D expertise as well as a well trained workforce who contribute as significantly in their primary functions. Every BSI staff are result-oriented professionals and are guided by high personal integrity.

Marrying the six prominent components of BSI core values, BSI aims to serve mankind globally based on dedication, professionalism and technical competency.

ALVELAC AND SOCKET PRESERVATION VIDEO

Understanding uniqueness of Alvelac by watching the video: Find out more about Socket Preservat [...]

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Submit a Question to Doctor Bone!

ASK DOCTOR BONE - SUBMIT A QUESTION
Got some things to clarify? Need more information? Send in your questions today
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Tuesday, September 1, 2009

FAQs

Question: My tooth hurts and I'm looking to extract it, how much will it cost? Answer: It costs around S$80-S$100 (non-subsidized) for a tooth extraction procedure to be done at public hospitals currently. Question: What can I do to fill up the gap after extracting my tooth? Answer: Prosthetics Dentistry can help you with restoration procedures like Fixed Bridges, Dentures or Dental Implants Question: What do the success and aesthetics of the restoration procedure depends on? Answer: Every structure requires a solid foundation to build on and that is the case with Bridges, Dentures and Implants. However the bone surrounding the extracted tooth starts to degrade and erode the moment the tooth is removed. The way to prevent this is through the socket preservation procedure that places materials in the socket to prevent bone loss. Question: What materials are available for socket preservation? Answer: Conventional materials include your own bone from other parts of your body, other human being's bone, animal bone or synthetic bone. Using your own bone means having surgery to extract bone from another part of your body which may cause further complications. Using another person or animal bone may result in rejection of the bone by your body's immune system. Current synthetic bones are made of bio-inert glass like materials and will stay in the body for several years. In addition they tend to break easily due to their glass like properties. Question: What is Bioscaff Alverlac and how is it different from the other socket preservation materials? Answer: Bioscaff™ Alvelac™ is a synthetic that has the advantage of being able to be formed in to [...]

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Ask your own Dentist about Socket Preservation

If your dentist has recommended that you undergo tooth extraction that  subsequently involves the use of bone graft to preserve your socket, you may have questions about the procedure, why you need it and what to expect throughout the process. These thoughts  are perfectly reasonable and your dentist should explain his views to you before you decide if you should go ahead with your procedure. To get you started, here are some sample questions for you to think about and you may like to print them out to ask your dentist when you go for the appointment.
  1. Why do I need bone grafting to preserve the socket?
    1. What types of bone graft materials are available?
    2. Are there any differences in efficacy, safety or possible side effects among the alternatives and the recommended bone grafting materials?
    3. Is an replacement such as Bioscaff™ Alvelac™ an option for me?
    4. What are the potential complications after the procedure?
    5. When can I expect to return to normal activity?
  2. Please describe the procedure to me.
    1. What happens during the procedure
    2. Will the procedure be done in the clinic or in the hospital?
    3. What are the pros and cons of this dental surgery?
    4. How large will my incision be and where will it be?
    5. Will it leave a scar, and if so, where?
    6. Will it be painful? describe how will it be like (level, duration, etc?)
    7. Is there anything I can do to lessen the pain?
    8. Is there an alternative procedure that could be done?
    9. Why do you recommend this procedure to me?
  3. What medications are involved?
    1. Is there any side effects?
    2. Any alternatives to these medications?
    3. Make a list of all the medications, vitamins and supplements currently taking.  Are there any possibl [...]

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What is Socket Preservation?

Socket Preservation is the procedure in which bone loss is prevented following teeth extraction. Saving the bone allows for tooth restoration work to be done successfully. Without sufficient bone quantity and quality, prosthetic dentistry that include Dental Implants, Fixed Bridges and Dentures do not have a solid foundation to anchor on. Even if the procedure can be done, it may not look pleasing to the eyes and will be apparent that the tooth is prosthetic due to its misfit with the gum. Prosthetic dentistry options are, Dental Implants [caption id="attachment_406" align="alignright" width="297" caption="Implant Exposed            Implant Supported"]Left: Implant Exposed  Right: Implant firmly in preserved bone[/caption] These are artificial tooth and root replacements that resemble a tooth or group of teeth. The more bone support there is, the stronger the implant replacements will be. Without Socket Preservation, the bone can degenerate to a point where implants can no longer be placed without having more complex and costly bone grafting procedures to artificially create the necessary support. Preventing bone loss is obviously much easier than recreating the bone later. [caption id="attachment_407" align="alignleft" width="297" caption="With Gap                                Perfect Fit"]With Gap   Perfect Fit[/c [...]

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Friday, August 28, 2009

Our Photo Gallery

MOU with Saveetha University of India for Joint Biomedical Research - Sep 23, 2007
Received Top-Tier Professional Enterprise Award
[...]

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Research & Development: Future Vision

Bio-scaffold International (BSI) is continuing its effort in R&D of the process methodology of scaffold to tailor the properties for new applications that are non-load bearing tissues as well as expand the application of current scaffold beyond non-load bearing soft tissues. BSI is hoping to develop new synthetic material bone substitutes, properties of which can be matched to bone properties to aid easy integration as well as shorten the healing time. Another application currently being explored is to enhance current scaffolds with additional features to extend the applications beyond the current one. BSI is also working towards delivering a scaffold for segmental repair and augmentation by controlling the process parameters to have good dimensional control and controlled degradation. Currently, scaffolds for hard tissue are either made using solid metals and ceramics ! especially for elderly patients where self healing is difficult. However, one of the limitation is the difference in mechanical properties between the hard tissue and that of the permanent scaffold, i.e., Cortical bone has a modulus of 7 - 30 GPa while most commonly used implants (permanent scaffolds) have modulus that are typically 4 to 5 times the bone modulus leading to complications such as stress shielding. BSI is also aiming at developing a porous implant (permanent scaffold) with tailored mechanical properties using the biomaterials currently used to overcome this limitation.

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Research & Development: Our Technology

Bio-scaffold International (BSI) is a home grown Biotechnology company based in Singapore has developed a process to fabricate non-load bearing tissue scaffolds, specially for Dental sockets and related products in collaboration with a team of researchers from A*STAR Singapore Institute of Manufacturing Technology and Clinicians from National University of Singapore. The product helps in preservation and conservation of bone height , volume and density eliminating the need for bone grafting at a later stage. BSI uses a US Food and Drug Administration (FDA) approved Poly lactico glycolic acid (PLGA) for fabrication of scaffold with pre-determined pore architecture and strength. The new method allows re-creation of the scaffold within a short time with the necessary physical and mechanical properties. The scaffold is designed for s! timulating the bone tissue healing and preservation of bone height,volume and density. The degradation rate of the scaffold is tailored to provide the necessary space for bone tissue healing.



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BioScaff Alvelac - Product Application

Bioscaff™ Alvelac™ is intended to be used as a scaffold for alveolar sockets after tooth extraction. After extraction, as part of the natural healing process, the tooth socket is usually filled with a blood clot and bone is eventually regenerated in a period of approximately two to six months. There would also be some degree of socket contraction and resorption which will result in the reduced bone height of the alveolus. A bio-scaffold is intended to help maintain the original height and width of the socket so that there would be minimal bone loss and a good bone structure. Bioscaff™ Alvelac™ is designed to maintain socket height and width, which will allow for natural bone healing. In addition, it will dissolve in approximately two to six months, and will not act as a source of infection. It will also help to facilitate future dental procedures, such as implants, denture! s or bridges. There would be obvious benefit for any patients contemplating dental implants as there would be less of a need for additional surgery like bone grafting for inadequate bony configuration after dental extraction. After tooth extraction:
  • Natural healing of dental socket is expected
  • Bone loss leading to decrease in alveolar bone height & width
  • Long term stability of implants affected
Preservation of bone height and volume is essential for
  • dental implant stability
  • denture stability
  • soft tissue aesthetics
  • maintaining the integrity of adjacent teeth
Bone preservation can be achieved by using Bioscaff™ Alvelac™
  • Alvelac™ restricts bone resorption & loss
  • Prevents collapse of alveolar ridge
  • Aids remodelling of bone to d [...]

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BioScaff Alvelac - Other Considerations

There are currently procedures to repair and grow new bone that are part of routine dental surgical care. The four most commonly performed dental bone grafting procedures are nerve repositioning, onlay grafting, ridge augmentation and sinus lift. In addition, other miscellaneous grafting procedures are performed. There are a number of bone graft materials available in dentistry today which can be classified into four different categories:

Recipient's Own Bone Autograft is the obtaining of bone graft materials from the patient's body and typically is the best choice of grafting procedure available now. However, autograft has its limitations, which include potential problems such as second site morbidity and patient discomfort in terms of harvesting of a graft from another part of the patients body.

Other Human Being's Bone Allograft is the obtaining of bone graft materials from other human being, which can be either a cadaver or living donor. The disadvantage of allograft is that the bone graft materials may be rejected by the recipient's immune system. This results in the patient having to put on anti-rejection medication.

Animal Bone Xenograft is the obtaining of bone graft materials from tissue of animal origin, which include bovine (cow's bone) or porcine (pig's bone). Similar to allograft, such bone graft materials may be rejected by the recipient's immune system and anti-rejection medication will have to be used.

Synthetic Bone Alloplast is the graft of an inert foreign body (i.e. metal or polymer). It is bio-inert and will n [...]

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BioScaff Alvelac - A Product Overview

pdt-alvelac01Bioscaff™ Alvelac™ is a porous PLGA (poly lactic co glycolic acid) scaffold produced using a proprietary and patented technology. PLGA, a non-toxic, biocompatible and biodegradable polymer, is FDA approved. The scaffold is designed with macro channels and micro-pores. The osteoblast will reproduce on the scaffold. Differentiation will take place subsequently, forming the required bone as the scaffold degrades. It breaks down into lactic acid and glycolic acid, which are metabolised in the body and excreted as carbon dioxide and water. This process typically occurs over a time frame of two to six months.

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Thursday, August 27, 2009

Post Dental Extraction Problems: What Happens When a Tooth is Extracted?

Post Dental Extraction Problems: What Happens When a Tooth is Extracted? Tooth extraction can result in several complications:-
  • Bone loss at the area where tooth is extracted, a decrease in bone height of up to 1.5mm within 3 months
  • Adjacent teeth may move into empty spaces disrupting alignment of teeth and their function
  • Biting force may exert pressure on remaining teeth causing them to loosen
  • Multiple loss of teeth result in the shrinkage of upper and lower jaw. This leads to the "collapse" of support for facial structures such as lips and cheeks, causing effects of
  • Pre-mature aging
Why Bone Loss is Detrimental After tooth extraction, you might opt for future tooth restoration options like dentures, bridges of implants. All of these require a strong jawbone foundation to function properly. As nature would have it, bone loss occurs instantly after tooth extraction. Bone height loss can be up to 1.5 mm in 3 months and decrease in the width of alveolar ridge can be as much as 50% within 12 months. Once bone is lost, it cannot be naturally replaced and this can compromise aesthetic and future tooth restoration. If the natural bone loss process is not immediately arrested after tooth extraction, the end result will always be insufficient bone volume.  This causes inward-sinking gum lines.  This renders a poor aesthetic appearance and difficulties for placement of delayed implants, dentures or bridges after tooth extraction.

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BioScaff Alvelac and Tooth Extraction

Post Dental Extraction Problems: What Happens When a Tooth is Extracted? Tooth extraction can result in several complications:-
  • Bone loss at the area where tooth is extracted, a decrease in bone height of up to 1.5mm within 3 months
  • Adjacent teeth may move into empty spaces disrupting alignment of teeth and their function
  • Biting force may exert pressure on remaining teeth causing them to loosen
  • Multiple loss of teeth result in the shrinkage of upper and lower jaw. This leads to the "collapse" of support for facial structures such as lips and cheeks, causing effects of
  • Pre-mature aging
Why Bone Loss is Detrimental After tooth extraction, you might opt for future tooth restoration options like dentures, bridges of implants. All of these require a strong jawbone foundation to function properly. As nature would have it, bone loss occurs instantly after tooth extraction. Bone height loss can be up to 1.5 mm in 3 months and decrease in the width of alveolar ridge can be as much as 50% within 12 months. Once bone is lost, it cannot be naturally replaced and this can compromise aesthetic and future tooth restoration. If the natural bone loss process is not immediately arrested after tooth extraction, the end result will always be insufficient bone volume.  This causes inward-sinking gum lines.  This renders a poor aesthetic appearance and difficulties for placement of delayed implants, dentures or bridges after tooth extraction.

Heard of Doctor Bone? Go to http://www.bio-scaffold.com to find out... See you there !

Who is Bio-Scaffold International (BSI)

Bio-Scaffold International (BSI), a Singapore based and innovative biotechnology Company, specializes in the development of bio-scaffolds for the replacement of human tissues including bones, joints and ligaments. With the corporate headquarter strategically located in Singapore and through mutually rewarding collaboration with her esteem partners, BSI is well positioned to provide such innovations.

BSI's strengths are in its R&D expertise as well as a well trained workforce who contribute as significantly in their primary functions. Every BSI staff are result-oriented professionals and are guided by high personal integrity.

Marrying the six prominent components of BSI core values, BSI aims to serve mankind globally based on dedication, professionalism and technical competency.


Alvelac and Socket Preservation Understanding uniqueness of Alvelac by watching the video: Alvelac and Socket Preservation

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Sunday, August 23, 2009

Bio-Scaffold International Featured in Business Times

BSI featured again in newspaper. This time in The Business Times on Sat, 15 Nov 2008, Pg 15

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Bio-Scaffold International Moves to a Bigger Office

Bio-Scaffold International is expanding and has moved to its new office at The Galen in Science Park III.

Do you know who is Doctor Bone? Go to http://www.bio-scaffold.com to find out... See you there ! Bio-Scaffold International (BSI)

MOU Signed with Saveetha University, India

Signed MOU & commenced additional clinical trials with Saveetha University, India.

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Clinical Trial in Singapore

Clinical Trial in Singapore approved by National Healthcare Group.

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In-Vitro and In-Vivo Tests Completed

Completed in-vitro and in-vivo tests.

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Implant and Bone Growth

Implant from iliac of rabbit showed bone growth and mineralization inside and outside of the bio-scaffold.

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Bio-Scaffold International - New Internal Structure Developed

New internal structure and refined post processing methodology developed.

Ask Doctor Bone TODAY at http://www.bio-scaffold.com See you there ! Bio-Scaffold International (BSI)

Saturday, August 22, 2009

Bio Scaffold, The Company

A new breakthrough!!

Bio-Scaffold International (BSI)
is a Singapore company incorporated in March 1999 to advance biomedical research. Its focus is in the development and manufacture of PLGA (Poly lactic co-glycolic acid) bio-scaffolds and tissue engineering for the replacement of human tissues including bones, ligaments and joints.


http://www.bio-scaffold.com